Education:

  • 1982, B.A. Agronomy, Guangxi Agricultural Institute, China.
  • 1986, M.S. Genetics, Academia Sinica, China.

    Adviser: Dr. Jigeng Li

    Thesis: Ultrastructure and membrane protein analysis of chloroplasts from pollen cultured albino plants.

  • 1994, Ph.D. Biochemistry and Biophysics, University of Houston, Houston, Texas.

    Adviser: Dr. William R. Widger

    Dissertation: A physical genome map of the unicellular cyanobacterium Synechococcus sp. Strain PCC 7002.

Experience:

  • Feb, 2001-present, Assistant professor, Virginia Institute for Psychiatric and Behavior Genetics, Virginia Commonwealth University, Richmond, Virginia. SNP technology development and large scale association studies for psychiatric traits.
  • Aug. 2000-Feb, 2001. Senior scientist, Curagen Corporation, New Haven, Conneticut. Genotyping using capillary electrophoresis, pyrosequencing.
  • July, 1999-July, 2000. Scientist, project leader, Cereon Genomics, LLC, Cambridge, Massachusetts. Development of single nucleotide polymorphism (SNP) markers for Arabidopsis and Maize, and implementation of high throughput genotyping technologies, specifically using FP-TDI and pyrosequencing technologies, for genetic mapping and positional cloning of QTL genes.
  • July, 1997 - June, 1999. Research Instructor, Washington University School of Medicine, St. Louis, Missouri. SNP markers discovery and high throughput genotyping technologies development. FP-TDI was invented.
  • May 1994 - June 1997. Post doctoral fellow, Washington University School of Medicine, St. Louis, Missouri. High throughput genotyping technologies developing, automated DNA sequencing and analysis. FRET-TDI and FRET-DOL were invented.
  • Nov. 1993 - April. 1994. Research scientist at Agis Pharmaceutical, Inc., Houston, Texas. Searching for the genes involving in cell senescence and cycle.
  • Sept. 1986- Aug. 1988. Research scientist at Genetic Institute, Academia Sinica, Beijing, China. Immunochemical analysis of a phyto-pathogen causing plant brush disease.

Patent:

  1. Pui-Yan Kwok, Xiangning Chen and Leanna Levine, 2001. Fluorescence polarization in nucleic acid analysis. US patent 6180408.
  2. Pui-Yan Kwok and Xiangning Chen. 1999. Methods and kits for nucleic acid analysis using fluorescence resonance energy transfer. US Patent 5945283.

Publication:

  1. Xiangning Chen, Leanna Levine and Pui-Yan Kwok. 1999. Fluorescence polarization in homogeneous nucleic acid analysis. Genome Res. 9: 492-498. [Abstract |Full text | PDF reprint]
  2. Xiangning Chen and Pui-Yan Kwok. 1999. Homogeneous Genotyping Assays for Single Nucleotide Polymorphisms with Fluorescence Resonance Energy Transfer Detection. Genetic Analysis (Biomolecular Engineering). 14:157-163. [Abstract]
  3. Xiangning Chen, Kenneth J. Livak and Pui-Yan Kwok. 1998. A homogeneous, ligase-mediated DNA diagnostic test. Genome Res. 8: 549-556. [Abstract | Full text | PDF reprint]
  4. Pui-Yan Kwok and Xiangning Chen. 1998. Detection of single nucleotide variations. In Genetic Engineering: Principles and methods.  Ed. Setlow, J. K.  Plenum Press New York. 20: 125-134.
  5. Xiangning Chen, Barbara Zehnbauer, Andreas Gnirke and Pui-Yan Kwok.1997. Fluorescence energy transfer detection as a homogeneous DNA diagnostic method. Proc. Natl. Acad. Sci. USA. 94:10756-10761. [Abstract | Full text | PDF reprint]
  6. Xiangning Chen and Pui-Yan Kwok. 1997. Template-directed dye-terminator incorporation (TDI) assay: a homogeneous DNA diagnostic method based on fluorescence resonance energy transfer. Nucleic Acids Res. 25: 347-353. [Abstract | Full text | PDF reprint]
  7. William R. Widger, Xiangning Chen, and. Hrissi Samartzidou. 1997. The physical Genome map of Synechococcus PCC 7002. In Bacterial Genomes: Physical Structure and Analysis Eds. deBruijn, F.J., Lupski, J.R., and Weinstock, G. Chapman & Hall New York, New York. pp. 763-770.
  8. Xiangning Chen and William R. Widger. 1993. Physical genome map of the unicellular cyanobacterium Synechococcus sp. strain PCC 7002. J. Bacteriol. 175: 5106-5116. [Abstract]
  9. Xiangning Chen, Yuxiang Li and Jigeng Li. 1988. Ultrastructural and protein analysis of rice and wheat albinos by pollen culture. Yichuan Xuebao 15: 95-101. [Abstract]

Honor and Funding:

National research service awards (NRSA) from National Institute of Health (1-F32-HG00156-01), April, 1996-March, 1998

Technologies for diallelic marker discovery and testing.  NIH: 1R01 HG01720-01 (9/20/1997-8/31/2000), Co-PI.

New methods for high throughput genome analysis. NIH: 1R01 HG01864-01 (12/01/1998-11/30/2001), Co-PI.

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Last revised: January 13, 2004.